Ontology highlight
ABSTRACT:
SUBMITTER: Cammisotto V
PROVIDER: S-EPMC7222182 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Cammisotto Vittoria V Pastori Daniele D Nocella Cristina C Bartimoccia Simona S Castellani Valentina V Marchese Cinzia C Scavalli Antonio Sili AS Ettorre Evaristo E Viceconte Nicola N Violi Francesco F Pignatelli Pasquale P Carnevale Roberto R
Antioxidants (Basel, Switzerland) 20200402 4
<h4>Background</h4>High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) is predictive of cardiovascular events (CVEs) in atrial fibrillation (AF). We hypothesized that PCSK9 may directly induce platelet activation (PA).<h4>Methods</h4>We measured platelet aggregation, recruitment, Thromboxane B2 (TxB2) formation and soluble P-selectin levels as markers of PA and soluble Nox2-derived peptide (sNox2-dp), H<sub>2</sub>O<sub>2</sub>, isoprostanes and oxidized Low-Density-Lipoprotein (oxLD ...[more]