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Computational models of melanoma.

ABSTRACT: Genes, proteins, or cells influence each other and consequently create patterns, which can be increasingly better observed by experimental biology and medicine. Thereby, descriptive methods of statistics and bioinformatics sharpen and structure our perception. However, additionally considering the interconnectivity between biological elements promises a deeper and more coherent understanding of melanoma. For instance, integrative network-based tools and well-grounded inductive in silico research reveal disease mechanisms, stratify patients, and support treatment individualization. This review gives an overview of different modeling techniques beyond statistics, shows how different strategies align with the respective medical biology, and identifies possible areas of new computational melanoma research.

SUBMITTER: Albrecht M

PROVIDER: S-EPMC7222475 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Computational models of melanoma.

Albrecht Marco M Lucarelli Philippe P Kulms Dagmar D Sauter Thomas T

Theoretical biology & medical modelling 20200514 1

Genes, proteins, or cells influence each other and consequently create patterns, which can be increasingly better observed by experimental biology and medicine. Thereby, descriptive methods of statistics and bioinformatics sharpen and structure our perception. However, additionally considering the interconnectivity between biological elements promises a deeper and more coherent understanding of melanoma. For instance, integrative network-based tools and well-grounded inductive in silico research ...[more]

PMID: 32410672

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