Ontology highlight
ABSTRACT:
SUBMITTER: Lee D
PROVIDER: S-EPMC7222626 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lee Donghee D Erickson Alek A Dudley Andrew T AT Ryu Sangjin S
Journal of visualized experiments : JoVE 20190913 151
Mechanical stimuli are known to modulate biological functions of cells and tissues. Recent studies have suggested that compressive stress alters growth plate cartilage architecture and results in growth modulation of long bones of children. To determine the role of compressive stress in bone growth, we created a microfluidic device actuated by pneumatic pressure, to dynamically (or statically) compress growth plate chondrocytes embedded in alginate hydrogel cylinders. In this article, we describ ...[more]