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Next-generation influenza vaccines: opportunities and challenges.

ABSTRACT: Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains. Developing improved vaccines that elicit broader immunity remains a public health priority. Immune responses to current vaccines focus on the haemagglutinin head domain, whereas next-generation vaccines target less variable virus structures, including the haemagglutinin stem. Strategies employed to improve vaccine efficacy involve using structure-based design and nanoparticle display to optimize the antigenicity and immunogenicity of target antigens; increasing the antigen dose; using novel adjuvants; stimulating cellular immunity; and targeting other viral proteins, including neuraminidase, matrix protein 2 or nucleoprotein. Improved understanding of influenza antigen structure and immunobiology is advancing novel vaccine candidates into human trials.

SUBMITTER: Wei CJ

PROVIDER: S-EPMC7223957 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Next-generation influenza vaccines: opportunities and challenges.

Wei Chih-Jen CJ Crank Michelle C MC Shiver John J Graham Barney S BS Mascola John R JR Nabel Gary J GJ

Nature reviews. Drug discovery 20200214 4

Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains. Developing improved vaccines that elicit broader immunity remains a public health priority. Immune responses to current vaccines focus on the haemagglutinin head domain, whereas next-generation vaccines target less variable virus structures, including the haemagglutinin stem. Strategies employed to improve vaccine efficacy involve using structure-based design and nanoparticle display to optimize the antigeni ...[more]

PMID: 32060419

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