Emotion-Cognition Interactions in Attention-Deficit/Hyperactivity Disorder: Increased Early Attention Capture and Weakened Attentional Control in Emotional Contexts.
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ABSTRACT: Background
Emotion dysregulation is a key dimensional trait in psychopathology. It is of particular interest in attention-deficit/hyperactivity disorder (ADHD) because individual differences in emotion dysregulation predict impairment. Despite growing recognition of its importance, an understanding of emotional functioning in ADHD needs to be better integrated with the well-known nonemotional attentional impairments in the disorder. Here, we assess differences in early, reactive and later, regulatory attention to emotional stimuli, as well as how impairments in attentional control to nonemotional stimuli are affected under different emotional contexts.Methods
In all, 130 adolescents (nADHD = 61) completed an emotional go/no-go task while 32-channel electroencephalography data were recorded. Reaction time and accuracy were analyzed using the linear ballistic accumulator model.Results
The multimethod approach provided convergent evidence of increased early, reactive attention capture and overarousal (faster drift rates, increased P1) by positively valenced stimuli in ADHD, but no differences in later attention to emotional stimuli. Overarousal in positive-valence contexts appeared to exacerbate existing ADHD-related impairments in attentional control to nonemotional stimuli as well (reduced N2 amplitude). In contrast, positive-valence contexts facilitated attentional control to nonemotional stimuli for typically developing adolescents.Conclusions
Results highlight the dynamic interaction of emotion with attentional control in ADHD. Distinguishing reactive and regulatory contributions to emotion dysregulation has been informative for clarifying mechanisms and spurring the development of novel interventions in other disorders. It can be informative in ADHD as well.
SUBMITTER: Karalunas SL
PROVIDER: S-EPMC7224233 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:BACKGROUND:There are suggestions that patients with attention-deficit/hyperactivity disorder (ADHD) show impairment in executive attention control and emotion regulation. This study investigated emotion regulation as a function of the recruitment of executive attention in patients with ADHD. METHODS:Thirty-five healthy children/adolescents (mean age = 13.91) and twenty-six children/adolescents with ADHD (mean age = 14.53) participated in this fMRI study. They completed the affective Stroop paradigm viewing positive, neutral and negative images under varying cognitive loads. A 3-way ANOVA (diagnosis-by-condition-by-emotion) was conducted on the BOLD response data. Following this, 2 3-way ANOVAs (diagnosis-by-condition-by-emotion) were applied to context-dependent psychophysiological interaction (gPPI) analyses generated from a dorsomedial frontal cortex and an amygdala seed (identified from the BOLD response ANOVA main effects of condition and emotion respectively). RESULTS:A diagnosis-by-condition interaction within dorsomedial frontal cortex revealed reduced recruitment of dorsomedial frontal cortex as a function of increased task demands in the children/adolescents with ADHD relative to healthy children/adolescents. The level of reduction in recruitment of dorsomedial frontal cortex was significantly correlated with symptom severity (total and hyperactivity) measured by Conner's Parent Report Scale in the children/adolescents with ADHD. In addition, analysis of gPPI data from a dorsomedial frontal cortex seed revealed significant diagnosis-by-condition interactions within lateral frontal cortex; connectivity between dorsomedial frontal cortex and lateral frontal cortex was reduced in the patients with ADHD relative to comparison youth during congruent and incongruent task trials relative to view trials. There were no interactions of group, or main effect of group, within the amygdala in the BOLD response ANOVA (though children/adolescents with ADHD showed increased responses to positive images within temporal cortical regions during task trials; identified by the diagnosis-by-condition-by-emotion interaction). However, analysis of gPPI data from an amygdala seed revealed decreased connectivity between amygdala and lentiform nucleus in the presence of emotional stimuli in children/adolescents with ADHD (diagnosis-by-emotion interaction). CONCLUSION:The current study demonstrated disrupted recruitment of regions implicated in executive function and impaired connectivity within those regions in children/adolescents with ADHD. There were also indications of heightened representation of emotional stimuli in patients with ADHD. However, as the findings were specific for positive stimuli, the suggestion of a general failure in emotion regulation in ADHD was not supported.
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