Heterogeneity of neoantigen landscape between primary lesions and their matched metastases in lung cancer.

ABSTRACT:

Background

Personalized cancer vaccines based on tumor-derived neoantigens have shown strong and long-lasting antitumor effect in patients with some solid tumors. However, whether neoantigens identified from primary lesions could represent their metastatic lesions, and consequently the effect of vaccine therapy remained unknown.

Methods

To investigate whether neoantigens identified from primary tumors are similar to their matched metastases in lung cancer, we identified 79 samples from 24 cases. All of samples were collected before any systemic therapy. Major criteria for neoantigen identification included: derived from tumor-specific mutations, fold change >10 comparing to germline expression level, high predicted human leukocyte antigen (HLA) binding affinity and peptide o

SUBMITTER: Jiang T 

PROVIDER: S-EPMC7225166 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature