Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC7225306 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Shaokun S Huang Tanxiao T Liu Ming M He Wenlong W Zhao YingShen Y Yang Lizhen L Long Yingjiao Y Zong Dandan D Zeng Huihui H Liu Yuanyuan Y Liao Wenting W Duan Jingxian J Gong Subo S Chen Shifu S
Frontiers in oncology 20200508
Anaplastic lymphoma kinase (ALK) fusion events account for ~3-7% genetic alterations in patients with non-small cell lung cancer (NSCLC). In this study, we identified the ALK fusion patterns and a novel ALK fusion partner in 44 ALK positive NSCLC patients using a customized HapOncoCDx panel, and identified ALK fusion partners. The most common partner is EML4, forming the variant 1 (v1, E13:A20, 18/44), variant 2 (v2, E20:A20, 5/44), and variant 3 (v3, E6:A20, 13/44). Moreover, we detected a new ...[more]