Ontology highlight
ABSTRACT:
SUBMITTER: Dekkers JF
PROVIDER: S-EPMC7225674 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Dekkers Johanna F JF Whittle James R JR Vaillant François F Chen Huei-Rong HR Dawson Caleb C Liu Kevin K Geurts Maarten H MH Herold Marco J MJ Clevers Hans H Lindeman Geoffrey J GJ Visvader Jane E JE
Journal of the National Cancer Institute 20200501 5
Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Emerging evidence suggests that the distinct subtypes reflect the repertoire of genetic alterations and the target cell. However, the precise initiating events that predispose normal epithelium to neoplasia are poorly understood. Here, we demonstrate that breast epithelial organoids can be generated from human reduction mammoplasties (12 out of 12 donors), thus creating ...[more]