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Role of BET Inhibitors in Triple Negative Breast Cancers.

ABSTRACT: Bromodomain and extraterminal domain (BET) proteins have evolved as key multifunctional super-regulators that control gene expression. These proteins have been shown to upregulate transcriptional machinery leading to over expression of genes involved in cell proliferation and carcinogenesis. Based on favorable preclinical evidence of BET inhibitors in various cancer models; currently, 26 clinical trials are underway in various stages of study on various hematological and solid organ cancers. Unfortunately, preliminary evidence for these clinical studies does not support the application of BET inhibitors as monotherapy in cancer treatment. Furthermore, the combinatorial efficiency of BET inhibitors with other chemo-and immunotherapeutic agents remain elusive. In this review, we will provide a concise summary of the molecular basis and preliminary clinical outcomes of BET inhibitors in cancer therapy, with special focus on triple negative breast cancer.

SUBMITTER: Khandekar D

PROVIDER: S-EPMC7226117 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Role of BET Inhibitors in Triple Negative Breast Cancers.

Khandekar Durga D Tiriveedhi Venkataswarup V

Cancers 20200325 4

Bromodomain and extraterminal domain (BET) proteins have evolved as key multifunctional super-regulators that control gene expression. These proteins have been shown to upregulate transcriptional machinery leading to over expression of genes involved in cell proliferation and carcinogenesis. Based on favorable preclinical evidence of BET inhibitors in various cancer models; currently, 26 clinical trials are underway in various stages of study on various hematological and solid organ cancers. Unf ...[more]

PMID: 32218352

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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