Ontology highlight
ABSTRACT:
SUBMITTER: Abate A
PROVIDER: S-EPMC7226156 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Abate Andrea A Rossini Elisa E Bonini Sara Anna SA Fragni Martina M Cosentini Deborah D Tiberio Guido Albero Massimo GAM Benetti Diego D Hantel Constanze C Laganà Marta M Grisanti Salvatore S Terzolo Massimo M Memo Maurizio M Berruti Alfredo A Sigala Sandra S
Cancers 20200409 4
Mitotane is the only drug approved for the treatment of adrenocortical carcinoma (ACC). The regimen to be added to mitotane is a chemotherapy including etoposide, doxorubicin, and cisplatin. This pharmacological approach, however, has a limited efficacy and significant toxicity. Evidence indicates that ACC seems to be sensitive to alkylating agents. Trabectedin is an anti-tumor drug that acts as an alkylating agent with a complex mechanism of action. Here, we investigated whether trabectedin cou ...[more]