Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC7226213 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Liu Huisi H Zheng Sanduo S Hou Xinfeng X Liu Ximing X Du Kaixin K Lv Xueyuan X Li Yulu Y Yang Fang F Li Wenhui W Sui Jianhua J
Cancer science 20200320 5
Hepatocellular carcinoma (HCC) is a common and particularly fatal form of cancer for which very few drugs are effective. The fibroblast growth factor 19 (FGF19) has been viewed as a driver of HCC development and a potential Ab target for developing novel HCC therapy. However, a previously developed anti-FGF19 Ab disrupted FGF19's normal regulatory function and caused severe bile-acid-related side-effects despite of having potent antitumor effects in preclinical models. Here, we developed novel h ...[more]