Ontology highlight
ABSTRACT:
SUBMITTER: Schochter F
PROVIDER: S-EPMC7226269 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Schochter Fabienne F Werner Kim K Köstler Cäcilia C Faul Anke A Tzschaschel Marie M Alberter Barbara B Müller Volkmar V Neubauer Hans H Fehm Tanja T Friedl Thomas W P TWP Polzer Bernhard B Janni Wolfgang W Rack Brigitte B Wiesmüller Lisa L
Cancers 20200409 4
Evidence suggests that the DNA end-binding protein p53-binding protein 1 (53BP1) is down-regulated in subsets of breast cancer. Circulating tumor cells (CTCs) provide accessible "biopsy material" to track cell traits and functions and their alterations during treatment. Here, we prospectively monitored the 53BP1 status in CTCs from 67 metastatic breast cancer (MBC) patients with HER2- CTCs and known hormone receptor (HR) status of the primary tumor and/or metastases before, during, and at the en ...[more]