Ontology highlight
ABSTRACT:
SUBMITTER: Andring J
PROVIDER: S-EPMC7226357 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Andring Jacob J Combs Jacob J McKenna Robert R
Biomolecules 20200331 4
Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO<sub>2</sub>/HCO<sub>3</sub><sup>-</sup>. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic acid), an everyday over-the-counter drug, has both ester and carboxylic acid moieties. Recently, compounds with a carboxylic acid group have been shown to inhibit CAII. Hence, we hypothesized that Aspirin could act as a substrate for es ...[more]