Kynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients.
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ABSTRACT:
SUBMITTER: Gonzalez-Sanchez M
PROVIDER: S-EPMC7226436 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Kynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients.
González-Sánchez Marta M Jiménez Javier J Narváez Arantzazu A Antequera Desiree D Llamas-Velasco Sara S Martín Alejandro Herrero-San AH Arjona Jose Antonio Molina JAM Munain Adolfo López de AL Bisa Alberto Lleó AL Marco M-Pilar MP Rodríguez-Núñez Montserrat M Pérez-Martínez David Andrés DA Villarejo-Galende Alberto A Bartolome Fernando F Domínguez Elena E Carro Eva E
Biomolecules 20200408 4
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. Thus, altered KYNA levels may suggest an inflammatory response. Very recently, significant increases in KYNA levels were reported in cerebrospinal fluid (CSF) from AD patients compared with normal controls. In this study, we asse ...[more]
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