Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.
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ABSTRACT:
SUBMITTER: Hamid AB
PROVIDER: S-EPMC7226513 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.
Hamid Abdulaziz B AB Petreaca Ruben C RC
Cancers 20200409 4
Secondary resistant mutations in cancer cells arise in response to certain small molecule inhibitors. These mutations inevitably cause recurrence and often progression to a more aggressive form. Resistant mutations may manifest in various forms. For example, some mutations decrease or abrogate the affinity of the drug for the protein. Others restore the function of the enzyme even in the presence of the inhibitor. In some cases, resistance is acquired through activation of a parallel pathway whi ...[more]
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