Ontology highlight
ABSTRACT:
SUBMITTER: Hung PS
PROVIDER: S-EPMC7226522 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hung Pei-Shan PS Huang Ming-Hung MH Kuo Yuan-Yeh YY Yang James Chih-Hsin JC
Cancers 20200331 4
The <i>KRAS</i> mutations have been an obstacle to identify therapeutic targets in cancer treatment. In this work, we clarified the distinct metastasis pattern of non-small-cell lung carcinoma (NSCLC) induced by KRAS<sup>G12V</sup>/KRAS<sup>G12D</sup> mutations and inhibited the KRAS<sup>G12V</sup> mediated metastasis by Wnt inhibitor. First, we found that KRAS<sup>G12V</sup> induced more aggressive phenotype in vitro and in vivo experiments. The Gene Set Enrichment Analysis (GSEA) results of H8 ...[more]