Ontology highlight
ABSTRACT:
SUBMITTER: Catarino S
PROVIDER: S-EPMC7226732 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Cells 20200407 4
Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the autophagy receptor p62 to mediate binding to LC3B and degradation by macroautophagy. In this report, we describe a functional LC3 interacting region (LIR), present in the amino terminal of most Cx protein family members, which can mediate the autoph ...[more]