Ontology highlight
ABSTRACT:
SUBMITTER: Roosenboom B
PROVIDER: S-EPMC7226824 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Roosenboom Britt B Lochem Ellen G van EGV Meijer Jos J Smids Carolijn C Nierkens Stefan S Brand Eelco C EC Erp Liselot W van LWV Kemperman Larissa G J M LGJM Groenen Marcel J M MJM Horje Carmen S Horjus Talabur CSHT Wahab Peter J PJ
Cells 20200406 4
PNAd and MAdCAM-1 addressins on venules are of importance in T-cell homing and potential therapeutic targets in ulcerative colitis (UC). Normally, PNAd<sup>+</sup> high endothelial venules (HEVs) are only present in lymphoid organs, whereas small numbers of MAdCAM-1<sup>+</sup> venules can be seen in non-lymphoid tissue. We aimed to study their presence in the intestinal mucosa of UC patients at diagnosis and during follow-up, and their correlation with disease activity. Colonic biopsy specimens ...[more]