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Prognostic implication and functional exploration for microRNA-20a as a molecular biomarker of gastrointestinal cancer.


ABSTRACT: BACKGROUND:It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic value of miR-20a expression in GIC remains controversial. METHODS:We first conducted a comprehensive literature search of the clinical data and pooled them for evidence in assessing prognostic significance of miR-20a expression in GIC. Afterwards, we applied some bioinformatic analysis methods to explore the biological function of miR-20a and explain why miR-20a could act as an effective biomarker. RESULTS:The pooled results showed that enhanced miR-20a expression was significantly associated with poor survival in GIC patients (HR: 1.36; 95%CI: 1.21-1.52; P?

SUBMITTER: Peng Q 

PROVIDER: S-EPMC7227208 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Prognostic implication and functional exploration for microRNA-20a as a molecular biomarker of gastrointestinal cancer.

Peng Qiliang Q   Zhao Peifeng P   Shen Yi Y   Cheng Ming M   Wu Yongyou Y   Zhu Yaqun Y  

BMC cancer 20200514 1


<h4>Background</h4>It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic value of miR-20a expression in GIC remains controversial.<h4>Methods</h4>We first conducted a comprehensive literature search of the clinical data and pooled them for evidence in assessing prognostic significance of miR-20a expression in GIC. Afterwards, we applied some bio  ...[more]

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