Ontology highlight
ABSTRACT:
SUBMITTER: Chamcha V
PROVIDER: S-EPMC7227795 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Chamcha Venkateswarlu V Reddy Pradeep B J PBJ Kannanganat Sunil S Wilkins Courtney C Gangadhara Sailaja S Velu Vijayakumar V Green Richard R Law G Lynn GL Chang Jean J Bowen James R JR Kozlowski Pamela A PA Lifton Michelle M Santra Sampa S Legere Traci T Chea Lynette S LS Chennareddi Lakshmi L Yu Tianwei T Suthar Mehul S MS Silvestri Guido G Derdeyn Cynthia A CA Gale Michael M Villinger Francois F Hunter Eric E Amara Rama Rao RR
Science translational medicine 20191101 519
Activated CD4 T cells are a major target of HIV infection. Results from the STEP HIV vaccine trial highlighted a potential role for total activated CD4 T cells in promoting HIV acquisition. However, the influence of vaccine insert-specific CD4 T cell responses on HIV acquisition is not known. Here, using the data obtained from four macaque studies, we show that the DNA prime/modified vaccinia Ankara boost vaccine induced interferon γ (IFNγ<sup>+</sup>) CD4 T cells [T helper 1 (T<sub>H</sub>1) ce ...[more]