Ontology highlight
ABSTRACT:
SUBMITTER: Kaitu'u-Lino TJ
PROVIDER: S-EPMC7228948 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200515 1
Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a strong association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentrations at 36 weeks' gestation and low birthweight, an indicator of placental insufficiency. We generate a 4-tier risk model based on SPINT1 concentrations, where the hig ...[more]