Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
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ABSTRACT:
SUBMITTER: Kaitu'u-Lino TJ
PROVIDER: S-EPMC7228948 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
Kaitu'u-Lino Tu'uhevaha J TJ MacDonald Teresa M TM Cannon Ping P Nguyen Tuong-Vi TV Hiscock Richard J RJ Haan Nick N Myers Jenny E JE Hastie Roxanne R Dane Kirsten M KM Middleton Anna L AL Bittar Intissar I Sferruzzi-Perri Amanda N AN Pritchard Natasha N Harper Alesia A Hannan Natalie J NJ Kyritsis Valerie V Crinis Nick N Hui Lisa L Walker Susan P SP Tong Stephen S
Nature communications 20200515 1
Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a strong association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentrations at 36 weeks' gestation and low birthweight, an indicator of placental insufficiency. We generate a 4-tier risk model based on SPINT1 concentrations, where the hig ...[more]
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