Trajectory-modulated hippocampal neurons persist throughout memory-guided navigation.

ABSTRACT: Trajectory-dependent splitter neurons in the hippocampus encode information about a rodent's prior trajectory during performance of a continuous alternation task. As such, they provide valuable information for supporting memory-guided behavior. Here, we employed single-photon calcium imaging in freely moving mice to investigate the emergence and fate of trajectory-dependent activity through learning and mastery of a continuous spatial alternation task. In agreement with others, the quality of trajectory-dependent information in hippocampal neurons correlated with task performance. We thus hypothesized that, due to their utility, splitter neurons would exhibit heightened stability. We find that splitter neurons were more likely to remain active and retained more consistent spatial informati

SUBMITTER: Kinsky NR 

PROVIDER: S-EPMC7229120 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature