Ontology highlight
ABSTRACT:
SUBMITTER: Tiklova K
PROVIDER: S-EPMC7229159 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Tiklová Katarína K Nolbrant Sara S Fiorenzano Alessandro A Björklund Åsa K ÅK Sharma Yogita Y Heuer Andreas A Gillberg Linda L Hoban Deirdre B DB Cardoso Tiago T Adler Andrew F AF Birtele Marcella M Lundén-Miguel Hilda H Volakakis Nikolaos N Kirkeby Agnete A Perlmann Thomas T Parmar Malin M
Nature communications 20200515 1
Cell replacement is a long-standing and realistic goal for the treatment of Parkinson's disease (PD). Cells for transplantation can be obtained from fetal brain tissue or from stem cells. However, after transplantation, dopamine (DA) neurons are seen to be a minor component of grafts, and it has remained difficult to determine the identity of other cell types. Here, we report analysis by single-cell RNA sequencing (scRNA-seq) combined with comprehensive histological analyses to characterize intr ...[more]