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Profiles of criteria and non-criteria anti-phospholipid autoantibodies are associated with clinical phenotypes of the antiphospholipid syndrome.


ABSTRACT: Background:Specific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which may require specific therapies. Non-criteria aPLs are rarely evaluated and their role is yet to be defined. In the current study, we aimed to examine the association between criteria and non-criteria aPLs and APS phenotypes. Methods:Serum samples from 188 subjects, 130 APS patients and 58 controls were analyzed for the presence of 20 aPLs (IgG and IgM isotypes to cardiolipin (CL), beta2-glycoprotein1 (?2GP1), phosphatidic acid (P-acid), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine (PS), annexin-5 (AN) and prothrombin (PT) using a line immunoassay (GA Generic Assays, Germany). Sero-positivity to the different aPLs/aPLs profiles was correlated to APS phenotypes (i.e. arterial thrombosis, CNS manifestations, venous thrombosis, relapsing disease, obstetric morbidity). Results:In this cohort, arterial thrombosis was associated with accumulative number of???7/20 aPLs evaluated (OR 4.1; CI 95% 1.9-96, p?=?0.001) as well as the sole presence of aPT (IgG) (OR 2.3;CI 95% 1.1-5.1, p?=?0.03). CNS manifestations were linked with a profile of 4 aPLs (IgG): aPT, aPG, aPI and aAN (OR 2.6;CI 95% 1.1-6.3, p?=?0.03). Symptom-free period of???3 years was linked with lower number of aPLs and the presence of aPI (IgG) (OR 3.0;CI 95% 1.08-8.1, p?

SUBMITTER: Volkov I 

PROVIDER: S-EPMC7229627 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Profiles of criteria and non-criteria anti-phospholipid autoantibodies are associated with clinical phenotypes of the antiphospholipid syndrome.

Volkov Ilan I   Seguro Luciana L   Leon Elaine P EP   Kovács László L   Roggenbuck Dirk D   Schierack Peter P   Gilburd Boris B   Doria Andrea A   Tektonidou Maria G MG   Agmon-Levin Nancy N  

Auto- immunity highlights 20200515 1


<h4>Background</h4>Specific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which may require specific therapies. Non-criteria aPLs are rarely evaluated and their role is yet to be defined. In the current study, we aimed to examine the association between criteria and non-criteria aPLs and APS phenotypes.<h4>Methods</h4>Serum samples from 188 subjects,  ...[more]

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