Ontology highlight
ABSTRACT:
SUBMITTER: Warman EA
PROVIDER: S-EPMC7229825 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20200501 9
RNA polymerases initiate transcription at DNA sequences called promoters. In bacteria, the best conserved promoter feature is the AT-rich -10 element; a sequence essential for DNA unwinding. Further elements, and gene regulatory proteins, are needed to recruit RNA polymerase to the -10 sequence. Hence, -10 elements cannot function in isolation. Many horizontally acquired genes also have a high AT-content. Consequently, sequences that resemble the -10 element occur frequently. As a result, foreig ...[more]