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Effects of ?Bioactive ?Marine-Derived ?Liposomes on ?Two ?Human ?Breast Cancer ??Cell Lines.


ABSTRACT: Breast cancer is the leading ?cause of death from cancer ?among women. Higher ?consumption ?of ?dietary ?marine n-3 long-chain ?polyunsaturated fatty acids ??(LC-PUFAs) is associated ?with a ??lower risk of breast ?cancer. Eicosapentaenoic ?acid (EPA) and ?docosahexaenoic acid (DHA) ??are ?two n-3 LC-PUFAs found ?in fish and exert anticancer ?effects. In this study, ?natural ?marine-?derived ?lecithin that is rich in ?various polyunsaturated fatty acids (PUFAs) was extracted ?from salmon heads and ??transformed ?into ?nanoliposomes. These ?nanoliposomes were ?characterized and cultured ?with ?two breast ?cancer ?lines (MCF-7 and MDA-MB-??231). The nanoliposomes ?decreased the ?proliferation ?and ?the stiffness of both ?cancer cell types. These ?results suggest that marine-derived lecithin possesses ??anticancer properties, ?which may have an impact ?on developing new ??liposomal delivery ??strategies for breast cancer ?treatment.

SUBMITTER: Li J 

PROVIDER: S-EPMC7230201 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Effects of ‎Bioactive ‎Marine-Derived ‎Liposomes on ‎Two ‎Human ‎Breast Cancer ‎‎Cell Lines.

Li Jie J   Elkhoury Kamil K   Barbieux Claire C   Linder Michel M   Grandemange Stéphanie S   Tamayol Ali A   Francius Grégory G   Arab-Tehrany Elmira E  

Marine drugs 20200413 4


Breast cancer is the leading ‎cause of death from cancer ‎among women. Higher ‎consumption ‎of ‎dietary ‎marine n-3 long-chain ‎polyunsaturated fatty acids ‎‎(LC-PUFAs) is associated ‎with a ‎‎lower risk of breast ‎cancer. Eicosapentaenoic ‎acid (EPA) and ‎docosahexaenoic acid (DHA) ‎‎are ‎two n-3 LC-PUFAs found ‎in fish and exert anticancer ‎effects. In this study, ‎natural ‎marine-‎derived ‎lecithin that is rich in ‎various polyunsaturated fatty acids (PUFAs) was extracted ‎from salmon heads a  ...[more]

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