Ontology highlight
ABSTRACT:
SUBMITTER: Guerreiro IM
PROVIDER: S-EPMC7230458 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Guerreiro Inês Maria IM Barros-Silva Daniela D Lopes Paula P Cantante Mariana M Cunha Ana Luísa AL Lobo João J Antunes Luís L Rodrigues Ana A Soares Marta M Henrique Rui R Jerónimo Carmen C
Journal of clinical medicine 20200402 4
Lung cancer (LC) cells frequently express high levels of programmed death-ligand 1 (PD-L1). Although these levels grossly correlate with the likelihood of response to specific checkpoint inhibitors, the response prediction is rather imperfect, and more accurate predictive biomarkers are mandatory. We examined the methylation profile of <i>RAD51B</i> (<i>RAD51B<sup>me</sup></i>) as a candidate predictive biomarker for anti-PD-1 therapy efficacy in non-small cell lung cancer (NSCLC), correlating w ...[more]