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Effect of ?-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model.


ABSTRACT: New antibacterial treatments against Helicobacter pylori are needed as H. pylori is acquiring antibiotic resistance. ?-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from ?-caryophyllene on the eradication of H. pylori in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti-H.pylori efficacy of ?-caryophyllene, a total of 160 mice were divided into eight groups (n = 10 each) and were administered different treatments for 2 and 4 weeks. H. pylori eradication was assessed using a Campylobacter-like organism (CLO) test and H. pylori qPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively. H. pylori levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in H. pylori-infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment of H. pylori infection.

SUBMITTER: Jung DH 

PROVIDER: S-EPMC7230661 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Effect of β-caryophyllene from Cloves Extract on <i>Helicobacter pylori</i> Eradication in Mouse Model.

Jung Da Hyun DH   Park Mi Hee MH   Kim Chul Jin CJ   Lee Jin Young JY   Keum Chang Yeop CY   Kim In Seon IS   Yun Chang-Hyun CH   Kim Sung-Kyu SK   Kim Won Ho WH   Lee Yong Chan YC  

Nutrients 20200404 4


New antibacterial treatments against <i>Helicobacter pylori</i> are needed as <i>H. pylori</i> is acquiring antibiotic resistance. β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication of <i>H. pylori</i> in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti-<i>H.pylori</i> efficacy of β-caryophyllene, a total  ...[more]

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