MK-7 and Its Effects on Bone Quality and Strength.
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ABSTRACT:
SUBMITTER: Sato T
PROVIDER: S-EPMC7230802 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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MK-7 and Its Effects on Bone Quality and Strength.
Sato Toshiro T Inaba Naoko N Yamashita Takatoshi T
Nutrients 20200331 4
Vitamin K acts as a cofactor and is required for post-translational γ-carboxylation of vitamin K-dependent proteins (VKDP). The current recommended daily intake (RDI) of vitamin K in most countries has been established based on normal coagulation requirements. Vitamin K1 and menaquinone (MK)-4 has been shown to decrease osteocalcin (OC) γ-carboxylation at RDI levels. Among the several vitamin K homologs, only MK-7 (vitamin K2) can promote γ-carboxylation of extrahepatic VKDPs, OC, and the matrix ...[more]
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