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In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds.


ABSTRACT: Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (Halimeda spp., Spyridia hypnoides (Bory de Saint-Vincent) Papenfuss, Valoniopsis pachynema (G. Martens) Børgesen, Gracilaria fergusonii J. Agardh and Amphiroa anceps (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UHPLC-ESI-MS/MS). Furthermore, these seaweeds were assessed for antioxidant and inhibitory effects against ?-amylase, ?-glucosidase, acetyl-cholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase. Valoniopsis pachynema and A. anceps yielded the highest flavonoid (4.30 ± 0.29 mg RE/g) and phenolic content (7.83 ± 0.08 mg RE/g), respectively. Additionally, A. anceps exhibited significant antioxidant properties with all assays and significantly depressed BChE (IC50 = 6.68 ± 0.83 mg/mL) and ?-amylase activities (IC50 = 5.34 ± 0.14 mg/mL). Interestingly, the five seaweeds revealed potent inhibitory effects against tyrosinase activity. In conclusion, A. anceps might be considered as a key source of phytoantioxidants and a potential candidate to develop nutritional supplements. Besides, the five tested seaweeds warrant further study and may be exploited as promising natural sources for managing hyperpigmentation.

SUBMITTER: Mahomoodally MF 

PROVIDER: S-EPMC7230894 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds.

Mahomoodally Mohamad Fawzi MF   Bibi Sadeer Nabeelah N   Zengin Gokhan G   Cziáky Zoltán Z   Jekő József J   Diuzheva Alina A   Sinan Kouadio Ibrahime KI   Palaniveloo Kishneth K   Kim Doo Hwan DH   Rengasamy Kannan Rr KR  

Marine drugs 20200408 4


Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (<i>Halimeda</i> spp., <i>Spyridia hypnoides</i> (Bory de Saint-Vincent) Papenfuss, <i>Valoniopsis pachynema</i> (G. Martens) Børgesen, <i>Gracilaria fergusonii</i> J. Agardh and <i>Amphiroa anceps</i> (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (  ...[more]

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