Dataset Information

Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.

ABSTRACT: BACKGROUND:Disordered eating (DE) is common and is associated with body mass index (BMI). We investigated whether genetic variants for BMI were associated with DE. Methods: BMI polygenic scores (PGS) were calculated for participants of the Avon Longitudinal Study of Parents and Children (ALSPAC; N = 8654) and their association with DE tested. Data on DE behaviors (e.g., binge eating and compensatory behaviors) were collected at ages 14, 16, 18 years, and DE cognitions (e.g., body dissatisfaction) at 14 years. Mediation analyses determined whether BMI mediated the association between the BMI-PGS and DE. Results: The BMI-PGS was positively associated with fasting (OR = 1.42, 95% CI = 1.25, 1.61), binge eating (OR = 1.28, 95% CI = 1.12, 1.46), purging (OR = 1.20, 95% CI = 1.02, 1.42), body dissatisfaction (Beta = 0.99, 95% CI = 0.77, 1.22), restrained eating (Beta = 0.14, 95% CI = 0.10, 1.17), emotional eating (Beta = 0.21, 95% CI = 0.052, 0.38), and negatively associated with thin ideal internalization (Beta = -0.15, 95% CI = -0.23, -0.07) and external eating (Beta = -0.19, 95% CI = -0.30, -0.09). These associations were mainly mediated by BMI. Conclusions: Genetic variants associated with BMI are also associated with DE. This association was mediated through BMI suggesting that weight potentially sits on the pathway from genetic liability to DE.

SUBMITTER: Abdulkadir M

PROVIDER: S-EPMC7231239 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.

Abdulkadir Mohamed M Herle Moritz M De Stavola Bianca L BL Hübel Christopher C Santos Ferreira Diana L DL Loos Ruth J F RJF Bryant-Waugh Rachel R Bulik Cynthia M CM Micali Nadia N

Journal of clinical medicine 20200421 4

<h4>Background</h4>Disordered eating (DE) is common and is associated with body mass index (BMI). We investigated whether genetic variants for BMI were associated with DE. <i>Methods</i>: BMI polygenic scores (PGS) were calculated for participants of the Avon Longitudinal Study of Parents and Children (ALSPAC; <i>N</i> = 8654) and their association with DE tested. Data on DE behaviors (e.g., binge eating and compensatory behaviors) were collected at ages 14, 16, 18 years, and DE cognitions (e.g. ...[more]

PMID: 32326247

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Project description:BACKGROUND:Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important to more accurately predict risk. METHODS:Using 3628 breast cancer cases and 5126 controls of European ancestry from eight case-control studies, we evaluated joint associations of a 77-single nucleotide polymorphism (SNP) PRS and quantitative mammographic density measures with breast cancer. Mammographic percent density and absolute dense area were evaluated using thresholding software and examined as residuals after adjusting for age, 1/BMI, and study. PRS and adjusted density phenotypes were modeled both continuously (per 1 standard deviation, SD) and categorically. We fit logistic regression models and tested the null hypothesis of multiplicative joint associations for PRS and adjusted density measures using likelihood ratio and global and tail-based goodness of fit tests within the subset of six cohort or population-based studies. RESULTS:Adjusted percent density (odds ratio (OR)?=?1.45 per SD, 95% CI 1.38-1.52), adjusted absolute dense area (OR?=?1.34 per SD, 95% CI 1.28-1.41), and the 77-SNP PRS (OR?=?1.52 per SD, 95% CI 1.45-1.59) were associated with breast cancer risk. There was no evidence of interaction of the PRS with adjusted percent density or dense area on risk of breast cancer by either the likelihood ratio (P?>?0.21) or goodness of fit tests (P?>?0.09), whether assessed continuously or categorically. The joint association (OR) was 2.60 in the highest categories of adjusted PD and PRS and 0.34 in the lowest categories, relative to women in the second density quartile and middle PRS quintile. CONCLUSIONS:The combined associations of the 77-SNP PRS and adjusted density measures are generally well described by multiplicative models, and both risk factors provide independent information on breast cancer risk.

Dataset Information

Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.

Publications

Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.

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