Ontology highlight
ABSTRACT:
SUBMITTER: Cloyd JM
PROVIDER: S-EPMC7231310 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Cloyd Jordan M JM Heh Victor V Pawlik Timothy M TM Ejaz Aslam A Dillhoff Mary M Tsung Allan A Williams Terence T Abushahin Laith L Bridges John F P JFP Santry Heena H
Journal of clinical medicine 20200415 4
The efficacy of neoadjuvant therapy (NT) versus surgery first (SF) for pancreatic ductal adenocarcinoma (PDAC) remains controversial. A random-effects meta-analysis of only prospective randomized controlled trials (RCTs) comparing NT versus SF for potentially resectable (PR) or borderline resectable (BR) PDAC was performed. Among six RCTs including 850 patients, 411 (48.3%) received NT and 439 (51.6%) SF. In all included trials, NT was gemcitabine-based: four using chemoradiation and two chemoth ...[more]