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Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study.


ABSTRACT: OBJECTIVES:To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan. METHODS:In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, treatment, and outcome were retrieved. Univariate and multivariate analyses were performed to explore potential factors. RESULTS:Overall, 147 patients with COVID-19 were included. The median duration of viral shedding (the number of days from symptoms onset until the successive negative detection of SARS-CoV-2 RNA) was 17 days (interquartile range [IQR], 12-21). Multivariate Logistic regression analysis indicated that the highest temperature at admission (odds ratio [OR], 5.200; 95% confidence interval [CI]: 1.190-22.726; p = 0.028), time from symptom onset to admission (OR, 1.740; 95% CI: 1.296-2.337; p < 0.001) and hospital length of stay (OR, 1.604; 95% CI: 1.262-2.040; p < 0.001) were risk factors for prolonged duration of viral shedding. CONCLUSIONS:This study, with a relatively large sample size, focused on the duration of viral shedding and related factors in patients with COVID-19, outside of Wuhan, China. Potential risk factors were identified and should be taken into consideration for the strategy of quarantining infected patients.

SUBMITTER: Qi L 

PROVIDER: S-EPMC7231495 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study.

Qi Lin L   Yang Yong Y   Jiang Dixuan D   Tu Chao C   Wan Lu L   Chen Xiangyu X   Li Zhihong Z  

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20200517


<h4>Objectives</h4>To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan.<h4>Methods</h4>In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, treatment, and outcome were retrieved. Univariate and multivariate analyses were performed to explore potential factors.<h4>Results</h4>Overall, 147 patients with COVID-19 were included. The  ...[more]

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