Ontology highlight
ABSTRACT:
SUBMITTER: Zanjani AAH
PROVIDER: S-EPMC7231890 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Biophysical journal 20200407 10
Several atomic structures have now been found for micrometer-scale amyloid fibrils or elongated microcrystals using a range of methods, including NMR, electron microscopy, and X-ray crystallography, with parallel β-sheet appearing as the most common secondary structure. The etiology of amyloid disease, however, indicates nanometer-scale assemblies of only tens of peptides as significant agents of cytotoxicity and contagion. By combining solution X-ray with molecular dynamics, we show that antipa ...[more]