Ontology highlight
ABSTRACT:
SUBMITTER: Alhammad YMO
PROVIDER: S-EPMC7232374 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Viruses 20200331 4
Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection. ADP-ribose is covalently attached to target proteins by poly-ADP-ribose polymerases (PARPs), using nicotinamide adenine dinucleotide (NAD+) as a substrate. This modification can have a wide variety of effects on proteins including alteration of enzyme activity, protein-protein interactions, and protein stabi ...[more]