Ontology highlight
ABSTRACT:
SUBMITTER: Clemencon B
PROVIDER: S-EPMC7232441 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Clémençon Benjamin B Kuhn-Nentwig Lucia L Langenegger Nicolas N Kopp Lukas L Peigneur Steve S Tytgat Jan J Nentwig Wolfgang W Lüscher Benjamin P BP
Toxins 20200412 4
The venom of <i>Cupiennius salei</i> is composed of dozens of neurotoxins, with most of them supposed to act on ion channels. Some insecticidal monomeric neurotoxins contain an α-helical part besides their inhibitor cystine knot (ICK) motif (type 1). Other neurotoxins have, besides the ICK motif, an α-helical part of an open loop, resulting in a heterodimeric structure (type 2). Due to their low toxicity, it is difficult to understand the existence of type 2 peptides. Here, we show with the volt ...[more]