Potential Therapeutic Targets of B7 Family in Colorectal Cancer.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC7232583 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Potential Therapeutic Targets of B7 Family in Colorectal Cancer.
Wang Changgang C Feng Haoran H Cheng Xi X Liu Kun K Cai Dongli D Zhao Ren R
Frontiers in immunology 20200505
Programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has impressively benefited cancer patients with a wide spectrum of tumors. However, its efficacy in colorectal cancer (CRC) is modest, and only a small subset of patients benefits from approved checkpoint inhibitors. Newer checkpoints that target additional immunomodulatory pathways are becoming necessary to activate durable antitumor immune responses in patients with CRC. In this review, we evaluated the m ...[more]
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