Ontology highlight
ABSTRACT:
SUBMITTER: Kathiriya JJ
PROVIDER: S-EPMC7233183 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Kathiriya Jaymin J JJ Brumwell Alexis N AN Jackson Julia R JR Tang Xiaodan X Chapman Harold A HA
Cell stem cell 20200123 3
Lung injury activates specialized adult epithelial progenitors to regenerate the epithelium. Depending on the extent of injury, both remaining alveolar type II cells (AEC2s) and distal airway stem/progenitors mobilize to cover denuded alveoli and restore normal barriers. The major source of airway stem/progenitors other than basal-like cells remains uncertain. Here, we define a distinct subpopulation (∼5%) of club-like lineage-negative epithelial progenitors (LNEPs) marked by high H2-K1 expressi ...[more]