Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution.

ABSTRACT:

Background

"Quantile-dependent expressivity" refers to a genetic effect that is dependent upon whether the phenotype (e.g., spirometric data) is high or low relative to its population distribution. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV₁), and the FEV₁/FVC ratio are moderately heritable spirometric traits. The aim of the analyses is to test whether their heritability (h² ) is constant over all quantiles of their distribution.

Methods

Quantile regression was applied to the mean age, sex, height and smoking-adjusted spirometric data over multiple visits in 9,993 offspring-parent pairs and 1,930 sibships from the Framingham Heart Study to obtain robust estimates of offspring-parent (β_OP), offspri

SUBMITTER: Williams PT 

PROVIDER: S-EPMC7233273 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature