Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia in Malawian Children.

ABSTRACT: BACKGROUND:Evidence regarding the appropriate duration of treatment with antibiotic agents in children with pneumonia in low-resource settings in Africa is lacking. METHODS:We conducted a double-blind, randomized, controlled, noninferiority trial in Lilongwe, Malawi, to determine whether treatment with amoxicillin for 3 days is less effective than treatment for 5 days in children with chest-indrawing pneumonia (cough lasting <14 days or difficulty breathing, along with visible indrawing of the chest wall with or without fast breathing for age). Children not infected with human immunodeficiency virus (HIV) who were 2 to 59 months of age and had chest-indrawing pneumonia were randomly assigned to receive amoxicillin twice daily for either 3 days or 5 days. Children were followed for 14 days.

SUBMITTER: Ginsburg AS 

PROVIDER: S-EPMC7233470 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature