Mendelian non-syndromic obesity.
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ABSTRACT:
SUBMITTER: Paolacci S
PROVIDER: S-EPMC7233639 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Mendelian non-syndromic obesity.
Paolacci Stefano S Pompucci Giuseppe G Paolini Barbara B Del Ciondolo Irene I Miggiano Giacinto Abele Donato GAD Aquilanti Barbara B Scaramuzza Andrea A Velluti Valeria V Matera Giuseppina G Gagliardi Lucilla L Bertelli Matteo M
Acta bio-medica : Atenei Parmensis 20190930 10-S
Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, ...[more]
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