Ontology highlight
ABSTRACT:
SUBMITTER: Luo W
PROVIDER: S-EPMC7233808 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Luo Wen W Xu Changxin C Phillips Sarah S Gardenswartz Aliza A Rosenblum Jeremy M JM Ayello Janet J Lessnick Stephen L SL Hao Huai-Xiang HX Cairo Mitchell S MS
Oncotarget 20200512 19
Ewing sarcoma (ES) is a malignant pediatric bone and soft tissue tumor. Patients with metastatic ES have a dismal outcome which has not been improved in decades. The major challenge in the treatment of metastatic ES is the lack of specific targets and rational combinatorial therapy. We recently found that protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is specifically highly expressed in ES and promotes tumor growth and metastasis in ES. In the current investigation, we show that PPP1R1A r ...[more]