Ontology highlight
ABSTRACT:
SUBMITTER: Thurner L
PROVIDER: S-EPMC7235000 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Thurner Lorenz L Hartmann Sylvia S Fadle Natalie N Regitz Evi E Kemele Maria M Kim Yoo-Jin YJ Bohle Rainer Maria RM Nimmesgern Anna A von Müller Lutz L Kempf Volkhard A J VAJ Weniger Marc A MA Neumann Frank F Schneider Nadine N Vornanen Martine M Sundström Christer C de Leval Laurence L Engert Andreas A Eichenauer Dennis A DA Küppers Ralf R Preuss Klaus-Dieter KD Hansmann Martin-Leo ML Pfreundschuh Michael M
Nature communications 20200518 1
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma of B-cell origin with frequent expression of functional B-cell receptors (BCRs). Here we report that expression cloning followed by antigen screening identifies DNA-directed RNA polymerase beta' (RpoC) from Moraxella catarrhalis as frequent antigen of BCRs of IgD<sup>+</sup> LP cells. Patients show predominance of HLA-DRB1*04/07 and the IgVH genes encode extraordinarily long CDR3s. High-titer, light-chain-restricted anti- ...[more]