Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC7235015 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Kim Yangsik Y Lee Jung Sun JS Joo Yeon Ho YH
Translational psychiatry 20200518 1
Rapamycin inhibits protein translation in cells, including neural stem cells (NSCs), by suppressing the mechanistic target of rapamycin (mTOR). This drug has been widely used together with calcineurin inhibitors in transplantation patients to prevent graft rejection. Previous studies have reported an association between mTOR and depression, but few investigations of this have occurred in transplant recipients. We have here tested the psychiatric effects of rapamycin in mice. The animals treated ...[more]