Loss of highwire Protects Against the Deleterious Effects of Traumatic Brain Injury in Drosophila Melanogaster.
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ABSTRACT:
SUBMITTER: Hill CS
PROVIDER: S-EPMC7235382 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Loss of <i>highwire</i> Protects Against the Deleterious Effects of Traumatic Brain Injury in <i>Drosophila Melanogaster</i>.
Hill Ciaran S CS Sreedharan Jemeen J Loreto Andrea A Menon David K DK Coleman Michael P MP
Frontiers in neurology 20200512
Traumatic brain injury is a major global cause of death and disability. Axonal injury is a major underlying mechanism of TBI and could represent a major therapeutic target. We provide evidence that targeting the axonal death pathway known as Wallerian degeneration improves outcome in a <i>Drosophila Melanogaster</i> model of high impact trauma. This cell-autonomous neurodegenerative pathway is initiated following axon injury, and in Drosophila, involves activity of the E3 ubiquitin ligase <i>hig ...[more]
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