Computational Prediction of Ubiquitination Proteins Using Evolutionary Profiles and Functional Domain Annotation.

ABSTRACT:

Background

Ubiquitination, as a post-translational modification, is a crucial biological process in cell signaling, apoptosis, and localization. Identification of ubiquitination proteins is of fundamental importance for understanding the molecular mechanisms in biological systems and diseases. Although high-throughput experimental studies using mass spectrometry have identified many ubiquitination proteins and ubiquitination sites, the vast majority of ubiquitination proteins remain undiscovered, even in well-studied model organisms.

Objective

To reduce experimental costs, computational methods have been introduced to predict ubiquitination sites, but the accuracy is unsatisfactory. If it can be predicted whether a protein can be ubiquitinated or not, it will help in predict

SUBMITTER: Qiu W 

PROVIDER: S-EPMC7235393 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature