RORγt-driven T_H17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex.

ABSTRACT: Epigenetic regulation, including chromatin accessibility and posttranslational modifications of histones, is of importance for T cell lineage decision. T_H17 cells play a critical role in protective mucosal immunity and pathogenic multiple autoimmune diseases. The differentiation of T_H17 cells is dictated by a master transcription factor, RORγt. However, the epigenetic mechanism that controls T_H17 cell differentiation remains poorly understood. Here we show that the Swi/Snf complex is required for T_H17-mediated cytokine production both in vitro and in vivo. We demonstrate that RORγt recruits and forms a complex with the Swi/Snf complex to cooperate for the RORγt-mediated epigenetic modifications of target genes, including both permissive and repre

SUBMITTER: Lee S 

PROVIDER: S-EPMC7235640 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature