Dataset Information

Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.

ABSTRACT: A precision health initiative was implemented across a multi-hospital health system, wherein a panel of genetic variants was tested and utilized in the clinical care of chronic kidney disease (CKD) patients. Pharmacogenomic predictors of antihypertensive response and genomic predictors of CKD were provided to clinicians caring for nephrology patients. To assess clinician knowledge, attitudes, and willingness to act on genetic testing results, a Likert-scale survey was sent to and self-administered by these nephrology providers (N = 76). Most respondents agreed that utilizing pharmacogenomic-guided antihypertensive prescribing is valuable (4.0 ± 0.7 on a scale of 1 to 5, where 5 indicates strong agreement). However, the respondents also expressed reluctance to use genetic testing for CKD risk stratification due to a perceived lack of supporting evidence (3.2 ± 0.9). Exploratory sub-group analyses associated this reluctance with negative responses to both knowledge and attitude discipline questions, thus suggesting reduced exposure to and comfort with genetic information. Given the evolving nature of genomic implementation in clinical care, further education is warranted to help overcome these perception barriers.

SUBMITTER: Spiech KM

PROVIDER: S-EPMC7235993 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.

Spiech Katherine M KM Tripathy Purnima R PR Woodcock Alex M AM Sheth Nehal A NA Collins Kimberly S KS Kannegolla Karthik K Sinha Arjun D AD Sharfuddin Asif A AA Pratt Victoria M VM Khalid Myda M Hains David S DS Moe Sharon M SM Skaar Todd C TC Moorthi Ranjani N RN Eadon Michael T MT

Life (Basel, Switzerland) 20200326 4

A precision health initiative was implemented across a multi-hospital health system, wherein a panel of genetic variants was tested and utilized in the clinical care of chronic kidney disease (CKD) patients. Pharmacogenomic predictors of antihypertensive response and genomic predictors of CKD were provided to clinicians caring for nephrology patients. To assess clinician knowledge, attitudes, and willingness to act on genetic testing results, a Likert-scale survey was sent to and self-administer ...[more]

PMID: 32224869

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Dataset Information

Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.

Publications

Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.

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