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ABSTRACT:
SUBMITTER: Zampieri D
PROVIDER: S-EPMC7236030 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Zampieri Daniele D Fortuna Sara S Calabretti Antonella A Romano Maurizio M Menegazzi Renzo R Schepmann Dirk D Wünsch Bernhard B Mamolo Maria Grazia MG
ACS medicinal chemistry letters 20191216 5
Among several potential applications, sigma receptor ligands can be used as antipsychotics, antiamnesics, and against other neurodegenerative disorders as well as neuroprotective agents. We present herein a new series of diazepane-containing derivatives as σR ligands obtained by a conformational expansion approach of our previously synthesized piperidine-based compounds. The best results were reached by benzofurane <b>2c</b>, <b>3c</b> and quinoline <b>2d</b>, <b>3d</b>-substituted diazepane der ...[more]