Radiotherapy for nonagenarians: the value of biological versus chronological age.

ABSTRACT: BACKGROUND:The number of nonagenarian cancer patients (? 90?years) is continuously increasing, and radiotherapy is performed in a relevant proportion of patients, as surgery and chemotherapy are often not feasible for these patients. However, the evidence regarding the feasibility and treatment outcomes after radiotherapy for this patient group is very limited. METHODS:All nonagenarian patients receiving (chemo) radiotherapy between 2009 and 2019 at the University of Freiburg - Medical Center were analyzed for patterns of care, overall survival (OS) and therapy-associated toxicities according to the Common Terminology Criteria for Adverse Events. Uni- and multivariate Cox regression analyses were conducted to assess the influence of patient- and treatment-related factors on patient outcomes. RESULTS:One hundred nineteen patients with a total of 137 irradiated lesions were included in this analysis. After a median follow-up of 27?months, median OS was 10?months with a 3-year OS amounting to 11.1%. Univariate analyses demonstrated that a reduced performance status (HR?=?1.56, 95% CI 1.00-2.45, p?

SUBMITTER: Sprave T 

PROVIDER: S-EPMC7236131 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature